Anti-SDHAF2 Antibody

Boster Bio Anti-SDHAF2 Antibody (Catalog # A07635) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

SDHAF2 (Succinate dehydrogenase complex assembly factor 2) encodes a mitochondrial protein needed for FAD cofactor attach to the SDH enzyme which plays a critical role in mitochondria. SDHAF2 is a tumor suppressor, but recent evidence suggests that somatic mutations of the SDHAF2 are unlikely to contribute to parathyroid tumor development in sporadic primary hyperparathyroidism.

Synonyms

PGL2, SDH5, C11orf79, PGL2, Succinate dehydrogenase assembly factor 2, mitochondrial, Succinate dehydrogenase subunit 5, SDH assembly factor 2

Gene Name

SDHAF2

UniProt

Q9NX18

Host

Chicken

Reactivity

Human, Mouse, Rat

Cross Reactivity

SDHAF2 antibody is predicted to not cross-react with other SDHAF protein family members.

Immunogen

SDHAF2 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SDHAF2. The immunogen is located within the first 50 amino acids of SDHAF2.

Clonality

Polyclonal

Applications

ELISA, WB

Field of Research

Cancer, Cell Cycle

Purification

SDHAF2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

Molecular Weight

19599 MW

Shipping Conditions

Available

Storage Conditions

SDHAF2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.