Anti-CHD7 Antibody

Boster Bio Anti-CHD7 Antibody (Catalog # A01533) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

CHD proteins belong to a superfamily of proteins of ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. These proteins are thought to play a role in early embryonic development by affecting chromatin structure and gene expression. Mutations in one member of this family, CHD7, result in CHARGE syndrome. It colocalizes with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes.

Synonyms

CRG, HH5, IS3, KAL5, KIAA1416, Chromodomain-helicase-DNA-binding protein 7, ATP-dependent helicase CHD7, CHD-7

Gene Name

CHD7

UniProt

Q9P2D1

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

Multiple isoforms of CHD7 are known to exist.

Immunogen

CHD7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CHD7. The immunogen is located within amino acids 670 - 720 of CHD7.

Clonality

Polyclonal

Tissue Specificity

Widely expressed in fetal and adult tissues.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Stem Cells

Purification

CHD7 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production.

Molecular Weight

335927 MW

Shipping Conditions

Available

Storage Conditions

CHD7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.