Anti-ORM1-like protein 1 ORMDL1 Antibody

Boster Bio Anti-ORM1-like protein 1 ORMDL1 Antibody (Catalog # A12278) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD) . Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.

Synonyms

ORM1-like protein 1, Adoplin-1

Gene Name

ORMDL1

UniProt

Q9P0S3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

ORMDL1 antibody may cross-react with other ORMDL protein family members.

Immunogen

ORMDL1 antibody was raised against a 16 amino acid synthetic peptide of human ORMDL1. The immunogen is located within amino acids 50 - 100 of ORMDL1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus. Expressed at intermediate level in pancreas, placenta and brain but low in skeletal muscle and lung.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Neuroscience

Purification

ORMDL1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Negative regulator of sphingolipid synthesis.

Molecular Weight

17371 MW

Shipping Conditions

Available

Storage Conditions

ORMDL1 antibody can be stored at 4 °C, stable for one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.