Anti-ZIMP7 ZMIZ2 Antibody

Boster Bio Anti-ZIMP7 ZMIZ2 Antibody (Catalog # A09987) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

ZIMP7, also known as ZMIZ2, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription) -like protein and a transcriptional coactivator. ZIMP7 is expressed most abundantly in testis. The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity and this activity is inhibited by the N-terminus in the full-length ZIMP7. ZIMP7 and the related protein ZIMP10 interact with PIAS3 and enhances Androgen Receptor (AR) - mediated transcription. The interaction between ZIMP7 and SWI/SNF complex suggests a possible role for ZIMP7 in chromatin modification.

Synonyms

NET27, ZIMP7, hZIMP7, TRAFIP20, KIAA1886, HRIHFB2007, Zinc finger MIZ domain-containing protein 2, PIAS-like protein Zimp7

Gene Name

ZMIZ2

UniProt

Q8NF64

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

At least four isoforms are known to exist. ZIMP7 antibody is predicted to not cross-react with other PIAS protein family members.

Immunogen

ZIMP7 antibody was raised against a 17 amino acid synthetic peptide near the center of human ZIMP7. The immunogen is located within amino acids 270 - 320 of ZIMP7.

Clonality

Polyclonal

Tissue Specificity

Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.

Applications

ELISA, WB

Field of Research

Signal Transduction

Purification

ZIMP7 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.

Molecular Weight

96537 MW

Shipping Conditions

Available

Storage Conditions

ZIMP7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.