Anti-Zinc finger MYM-type protein 3 ZMYM3 Antibody

Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM3 is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked mental retardation.

At least three isoforms of ZMYM3 are known to exist; this antibody will detect all three. ZMYM3 antibody is predicted to not cross-react with other ZMYM protein family members.

ZMYM3 antibody was raised against a 18 amino acid synthetic peptide near the center of human ZMYM3. The immunogen is located within amino acids 220 - 270 of ZMYM3.

ZMYM3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.