Anti-REQUIEM DPF2 Antibody

Requiem is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It is expressed in numerous tissues in both cytosolic and nuclear regions and likely serves a regulatory role in rapid hematopoietic cell growth and turnover. Requiem has been found to act as an adaptor protein that links the NF-κB and SWI/SNF chromatin remodeling factor and is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.

REQUIEM antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human Requiem. The immunogen is located within the last 50 amino acids of REQUIEM.

Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714) . Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407) . Might also have a role in the development and maturation of lymphoid cells (By similarity) . Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684) .

REQUIEM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.