Anti-ZIP8 SLC39A8 Antibody

Boster Bio Anti-ZIP8 SLC39A8 Antibody (Catalog # A04007) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Product Specifications

Background

The zinc transporter ZIP8, also known as SLC39A9, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA) . ZIP8 is glycosylated and located at the plasma membrane and mitochondria. It has been identified as the transporter responsible for transport of the toxic Cadmium cation. ZIP8 has also been suggested to play a role in the regulation of interferon-gamma expression in activated human T cells.

Synonyms

ZIP8, PP3105, BIGM103, LZT-Hs6, ZIP8, Zinc transporter ZIP8, BCG-induced integral membrane protein in monocyte clone 103 protein

Gene Name

SLC39A8

UniProt

Q9C0K1

Host

Rabbit

Reactivity

Human

Cross Reactivity

ZIP8 antibody is predicted to not cross-react with other ZIP family members.

Immunogen

ZIP8 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human ZIP8. The immunogen is located within the last 50 amino acids of ZIP8.

Clonality

Polyclonal

Tissue Specificity

Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Immunology

Purification

ZIP8 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Acts as a manganese and zinc influx transporter (PubMed:12504855, PubMed:26637978) . Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain (PubMed:26637978) .

Molecular Weight

49631 MW

Shipping Conditions

Available

Storage Conditions

ZIP8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04007

Product MSDS

https://www.bosterbio.com/msds?sku=A04007

Fragment

IgG

Other Gene Names

Solute carrier family 39 (zinc transporter), member 8

Subcellular Location

Membrane ; Multi-pass membrane protein . Associated with the lysosomal/endosomal compartment following transfection.

Prediction Reactivity

Mouse, Rat

Protein Name