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Anti-PEAR1 Antibody

Boster Bio Anti-PEAR1 Antibody (Catalog # A09593) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated; the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbbeta3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.

Synonyms

JEDI, MEGF12, Platelet endothelial aggregation receptor 1, Multiple epidermal growth factor-like domains protein 12, hPEAR1

Gene Name

PEAR1

UniProt

Q5VY43

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

PEAR1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human PEAR1. The immunogen is located within the last 50 amino acids of PEAR1.

Clonality

Polyclonal

Tissue Specificity

Expressed in umbilical vein endothelial cells and platelets (at protein level) . Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

PEAR1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. .

Molecular Weight

110666 MW

Shipping Conditions

Available

Storage Conditions

PEAR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Other Gene Names

Platelet endothelial aggregation receptor 1

Subcellular Location

Cell membrane ; Single-pass membrane protein . Detected on the cell surface in resting platelets.

Protein Name

Platelet endothelial aggregation receptor 1

Frequently Asked Questions

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