Anti-PLAC3 PAPPA2 Antibody
Boster Bio Anti-PLAC3 PAPPA2 Antibody (Catalog # A06838) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP) -5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
Synonyms
PAPPE, PLAC3, PAPP-E, PAPP-A2, Pappalysin-2, Pregnancy-associated plasma protein A2
Gene Name
PAPPA2
UniProt
Q9BXP8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
PLAC3 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human PLAC3. The immunogen is located within amino acids 450 - 500 of PLAC3.
Clonality
Polyclonal
Tissue Specificity
Expressed abundantly in placenta, and non- pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.
Applications
ELISA, WB, ICC, IF
Field of Research
Cancer, Cell Cycle
Purification
PLAC3 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP) -5 at the '163-Ser-
Molecular Weight
198539 MW
Shipping Conditions
Available
Storage Conditions
PLAC3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Other Gene Names
Pappalysin 2
Subcellular Location
Secreted .
Protein Name
Pappalysin 2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
