Anti-NALP10 NLRP10 Antibody

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1β , inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1β processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.

NALP10 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human NALP10. The immunogen is located within the first 50 amino acids of NALP10.

Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level) (PubMed:22672233) . Widely expressed with highest levels in heart, brain and skeletal muscle (PubMed:15096476) . Also expressed in liver, colon, dermis and epidermis (PubMed:15096476) . Little expression detected in myeloid cells or peripheral blood mononuclear cells (PubMed:15096476) .

Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476) . Displays anti-inflammatory activity (PubMed:20393137) . Required for immunity against C.albicans infection (By similarity) . Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233) . Contributes to T-cell-mediated inflammatory responses in the skin (By similarity) . Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990) . Exhibits both ATPase and GTPase activities (PubMed:23861819) .

NALP10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.