Anti-TCC52 DCAF12 Antibody

Boster Bio Anti-TCC52 DCAF12 Antibody (Catalog # A11802) . Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors. One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time.

Synonyms

CT102, TCC52, WDR40A, KIAA1892, DDB1- and CUL4-associated factor 12, Centrosome-related protein TCC52

Gene Name

DCAF12

UniProt

Q5T6F0

Host

Chicken

Reactivity

Human, Mouse, Rat

Immunogen

TCC52 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TCC52. The immunogen is located within amino acids 390 - 440 of TCC52.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis.

Applications

ELISA, WB, ICC

Field of Research

Cancer, Cell Cycle

Purification

TCC52 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Molecular Weight

50517 MW

Shipping Conditions

Available

Storage Conditions

TCC52 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.