Anti-Probable ribonuclease ZC3H12D ZC3H12D Antibody

ZC3H12D, also known as MCPIP4, is a member of a family of novel CCCH-zinc finger proteins that includes ZC3H12A, a protein that is thought to be involved in macrophage activation, host immunity and inflammatory diseases. ZC3H12D is highly expressed in spleen, intestine, and colon. Similar to ZC3H12A and ZC3H12C, ZC3H12D expression in murine macrophages is also increased after treatment with lipopolysaccharide (LPS), although not to the same level as ZC3H12A. This pattern of expression was not duplicated in human-derived macrophages, suggesting it also may play a different role in host immunity and inflammatory response.

ZC3H12D antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ZC3H12D. The immunogen is located within amino acids 280 - 330 of ZC3H12D.

May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561) . May function as RNase and regulate the levels of target RNA species (Potential) . In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560) . Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687) . Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561) .

ZC3H12D antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.