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Anti-NAT11 NAA40 Antibody

Boster Bio Anti-NAT11 NAA40 Antibody (Catalog # A13562) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

N-terminal acetylation is one of the most common protein modifications in eukaryotes, occurring on approximately 57% and 84% on yeast and human proteins respectively. There are several N-terminal acetylating enzyme complexes (NatA - NatE) . Unlike the other complexes, NatD is composed of a single protein, NAT11, and has recently been described to acetylate the Serine N-termini of histones H2A and H4 in yeast. The role these modifications play is unknown; yeast that do not express NAT11 grow at normal rates and have no observable phenotypes. The role of the human homolog is likewise unknown.

Synonyms

NAT11, PATT1, NAT11, N-alpha-acetyltransferase 40, N-acetyltransferase 11

Gene Name

NAA40

UniProt

Q86UY6

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

NAT11 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human NAT11. The immunogen is located within the last 50 amino acids of NAT11.

Clonality

Polyclonal

Tissue Specificity

Widely expressed; with the highest expression level in liver and the lowest expression in brain (at protein level) .

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

NAT11 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998) . In contrast to other N-alpha- acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg- Gly sequence' (PubMed:21935442, PubMed:25619998) . Acts as a negative regulator of apoptosis (PubMed:26666750) . May play a role in hepatic lipid metabolism (By similarity) .

Molecular Weight

27194 MW

Shipping Conditions

Available

Storage Conditions

NAT11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A13562

Product MSDS

https://www.bosterbio.com/msds?sku=A13562

Fragment

IgG

Other Gene Names

N (alpha) -acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)

Subcellular Location

Cytoplasm

Protein Name

N (alpha) -acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)

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