Anti-Girdin CCDC88A Antibody

Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.

Girdin antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus human Girdin. The immunogen is located within the last 50 amino acids of Girdin.

Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity) . Enhances phosphoinositide 3-kinase (PI3K) - dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity) . Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity) . Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227) . Required for formation of actin stress fibers and lamellipodia (PubMed:15882442) . May be involved in membrane sorting in the early endosome (PubMed:15882442) . Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382) .

Girdin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.