Anti-PLEKHM2 Antibody

PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.

SKIP, KIAA0842, SKIP, Pleckstrin homology domain-containing family M member 2, Salmonella-induced filaments A and kinesin-interacting protein, PH domain-containing family M member 2

PLEKHM2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human PLEKHM2. The immunogen is located within the last 50 amino acids of PLEKHM2.

May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation (PubMed:15905402) . May play a role in lysosomes movement and localization at the cell periphery (PubMed:25898167) .

PLEKHM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.