Anti-TMEM16B ANO2 Antibody

Boster Bio Anti-TMEM16B ANO2 Antibody (Catalog # A04801) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC's include the transmembrane proteins TMEM16A and TMEM16B. TMEM16B is predicted to have eight transmembrane domains with both the amino and carboxy termini in the cytoplasm and is expressed in several tissues including olfactory sensory neurons as well as photoreceptors in mammalian retina. Like TMEM16A, TMEM16B is thought to form at least part of CaCC's but has different biophysical characteristics such as voltage dependence and unitary conductance.

Synonyms

C12orf3, TMEM16B, C12orf3, Anoctamin-2, Transmembrane protein 16B

Gene Name

ANO2

UniProt

Q9NQ90

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

TMEM16B antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human TMEM16B. The immunogen is located within the first 50 amino acids of TMEM16B.

Clonality

Polyclonal

Tissue Specificity

Retina, especially in the photoreceptor synaptic terminals.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Neuroscience

Purification

TMEM16B Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.