Anti-KCTD15 Antibody

Childhood and adult obesity in the United States and to a lesser extent the rest of the world has increased dramatically over the past decade. Both environmental and genetic factors are involved in the onset and progression of weight gain. Recently, the potassium channel KCTD15 was identified as a genetic loci associated with higher than normal body mass index (BMI) in humans along with genes such as GNPDA2, MTCH2, FTO, and TMEM18. Further studies on single nucleotide polymorphisms (SNPs) in non-diabetic and diabetic patients showed that FTO was most strongly associated with obesity while MTCH2 and GNPDA2 were still significantly associated with higher than normal BMI levels. At least two isoforms of KCTD15 are known to exist.

KCTD15 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human KCTD15. The immunogen is located within the last 50 amino acids of KCTD15.

During embryonic development, interferes with neural crest formation (By similarity) . Inhibits AP2 transcriptional activity by interaction with its activation domain.

KCTD15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.