Anti-LRFN2 Antibody

Boster Bio Anti-LRFN2 Antibody (Catalog # A11623) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

LRFN2 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR) -immunoglobulin-like (Ig) -fibronectin type III (Fn) -transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system.

Synonyms

SALM1, FIGLER2, KIAA1246, SALM1, Leucine-rich repeat and fibronectin type-III domain-containing protein 2, Synaptic adhesion-like molecule 1

Gene Name

LRFN2

UniProt

Q9ULH4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least two isoforms of LRFN2 are known to exist. This antibody is predicted to not cross-react with other members of the LRFN family.

Immunogen

LRFN2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human LRFN2. The immunogen is located within amino acids 700 - 750 of LRFN2.

Clonality

Polyclonal

Tissue Specificity

Highest expression in heart, skeletal muscle and brain. Lower expression in all other tissues.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Neuroscience

Purification

LRFN2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity) . .

Molecular Weight

84731 MW

Shipping Conditions

Available

Storage Conditions

LRFN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.