Anti-Protein NipSnap homolog 3B NIPSNAP3B Antibody

The NIPSNAP proteins comprise a family of evolutionarily well-conserved proteins with strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. NIPSNAP2, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumors. While NIPSNAP3B is highly expressed skeletal muscle, NIPSNAP3A mRNA levels are low. NIPSNAP proteins have been suggested to be important in vesicular transport.

NIPSNAP3B antibody was raised against a 16 amino acid synthetic peptide near the center of human NIPSNAP3B. The immunogen is located within amino acids 40 - 90 of NIPSNAP3B.

Ubiquitous. Highly expressed in liver, kidney and muscle. Expressed at intermediate level in brain, heart, colon, thymus, kidney, small intestine, placenta, lung, leukocytes and spleen.

Acts as a transcriptional repressor (PubMed:20797634) . Represses cAMP-responsive element (CRE) -mediated transcriptional activation (PubMed:21706167) . In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165) . Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity) .

NIPSNAP3B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.