Anti-ZBTB1 Antibody

ZBTB1 is a zinc finger protein that also contains BTB (BR-C, ttk and bab) domain. While little is known about this protein or the related protein ZBTB2, its expression is known to be down-regulated in human bronchial epithelial cells in response to the presence of Vanadium. Recently, expression of variant ZBTB1 protein has been associated with increased age-related macular degeneration.

ZBTB1 antibody was raised against a 14 amino acid synthetic peptide near the center of human ZBTB1. The immunogen is located within amino acids 260 - 310 of ZBTB1.

Ubiquitous. Highly expressed in liver, kidney and muscle. Expressed at intermediate level in brain, heart, colon, thymus, kidney, small intestine, placenta, lung, leukocytes and spleen.

Acts as a transcriptional repressor (PubMed:20797634) . Represses cAMP-responsive element (CRE) -mediated transcriptional activation (PubMed:21706167) . In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165) . Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity) .

ZBTB1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.