Anti-Spred3 Antibody

Boster Bio Anti-Spred3 Antibody (Catalog # A15231) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Product Specifications

Background

Spred3 is a member of the Sprouty family, a group of proteins that act as negative regulators during development. Like Spred1 and Spred2, Spred3 contains and EVH1 domain in its amino terminus and a Sprouty-related cysteine-rich (SPR) domain in its C-terminus, but does not possess a functional c-kit binding domain (KBD) . The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Although Spred3 was initially reported to be expressed in brain, at least one report also indicates that Spred3 can be found in liver. At least two isoforms of Spred3 are known to exist.

Synonyms

Eve-3, spred-3, EVE-3, Sprouty-related, EVH1 domain-containing protein 3, Spred-3

Gene Name

SPRED3

UniProt

Q2MJR0

Host

Rabbit

Reactivity

Human

Cross Reactivity

This Spred3 antibody is predicted to have no cross-reactivity to Spred1 or Spred2.

Immunogen

Spred3 antibody was raised against a 16 amino acid synthetic peptide near the center of the human Spred3. The immunogen is located within amino acids 140 - 190 of Spred3.

Clonality

Polyclonal

Tissue Specificity

Expression is restricted to liver.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

Spred3 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. .

Molecular Weight

42670 MW

Shipping Conditions

Available

Storage Conditions

Spred3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.