Anti-Aldh5A1 Antibody

Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD (P) (+) -dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD (+) -dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA) . Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.

Aldh5A1 antibody was raised against a 22 amino acid synthetic peptide near the carboxy terminus of the human Aldh5A1. The immunogen is located within the last 50 amino acids of Aldh5A1.

Aldh5A1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.