Anti-Aldh5A1 Antibody

Boster Bio Anti-Aldh5A1 Antibody (Catalog # A03802) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD (P) (+) -dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD (+) -dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA) . Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.

Synonyms

SSDH, SSADH, Succinate-semialdehyde dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 5 member A1

Gene Name

ALDH5A1

UniProt

P51649

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Aldh5A1 antibody was raised against a 22 amino acid synthetic peptide near the carboxy terminus of the human Aldh5A1. The immunogen is located within the last 50 amino acids of Aldh5A1.

Clonality

Polyclonal

Tissue Specificity

Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.

Applications

ELISA, WB

Field of Research

Homeostasis

Purification

Aldh5A1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) .

Molecular Weight

57215 MW

Shipping Conditions

Available

Storage Conditions

Aldh5A1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.