Anti-Akirin-1 Akirin1 Antibody

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α and IL-1β signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Akirin1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of the human Akirin1. The immunogen is located within the first 50 amino acids of Akirin1.

Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933) . Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity) . Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460) . Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity) .

Akirin1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.