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Anti-GPAT1 GPAM Antibody

Boster Bio Anti-GPAT1 GPAM Antibody (Catalog # A05432) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets.

Synonyms

GPAT, GPAT1, KIAA1560, Glycerol-3-phosphate acyltransferase 1, mitochondrial, GPAT-1

Gene Name

GPAM

UniProt

Q9HCL2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least four isoforms of GPAT1 are known to exist; this antibody will detect only the two largest isoforms.

Immunogen

GPAT1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human GPAT1. The immunogen is located within amino acids 730 - 780 of GPAT1.

Clonality

Polyclonal

Tissue Specificity

Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Obesity

Purification

GPAT1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.

Molecular Weight

93795 MW

Shipping Conditions

Available

Storage Conditions

GPAT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A05432

Product MSDS

https://www.bosterbio.com/msds?sku=A05432

Fragment

IgG

Other Gene Names

Glycerol-3-phosphate acyltransferase, mitochondrial

Subcellular Location

Mitochondrion outer membrane

Prediction Reactivity

Pig, Bovine

Protein Name

Glycerol-3-phosphate acyltransferase, mitochondrial

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