Anti-Rim2 RIMS2 Antibody

Boster Bio Anti-Rim2 RIMS2 Antibody (Catalog # A09915-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.

Synonyms

OBOE, RIM2, RAB3IP3, KIAA0751, Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, RIM 2

Gene Name

RIMS2

UniProt

Q9UQ26

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

Multiple isoforms of RIM2 are known to exist. This antibody is predicted to have no cross-reactivity to other Rim proteins.

Immunogen

Rim2 antibody was raised against a 17 amino acid synthetic peptide near the center of the human Rim2. The immunogen is located within amino acids 250 - 300 of Rim2.

Clonality

Polyclonal

Tissue Specificity

Expressed in melanocytes (PubMed:23999003) .

Applications

ELISA, WB, IHC-P, IF

Field of Research

Neuroscience

Purification

Rim2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003) .

Molecular Weight

160403 MW

Shipping Conditions

Available

Storage Conditions

Rim2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Other Gene Names

Regulating synaptic membrane exocytosis 2

Subcellular Location

Cell membrane ; Peripheral membrane protein . Cell junction, synapse . Cell junction, synapse, presynaptic cell membrane ; Peripheral membrane protein .