Anti-EVER2 TMC8 Antibody

Boster Bio Anti-EVER2 TMC8 Antibody (Catalog # A06892-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc.

Synonyms

EV2, EVER2, EVIN2, Transmembrane channel-like protein 8, Epidermodysplasia verruciformis protein 2

Gene Name

TMC8

UniProt

Q8IU68

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least three isoforms of EVER2 are known to exist; this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.

Immunogen

EVER2 antibody was raised against a 14 amino acid synthetic peptide from near the center of human EVER2. The immunogen is located within amino acids 300 - 350 of EVER2.

Clonality

Polyclonal

Tissue Specificity

Expressed in placenta, prostate and testis.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

EVER2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Probable ion channel. .

Molecular Weight

81641 MW

Shipping Conditions

Available

Storage Conditions

EVER2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.