Anti-EVER1 TMC6 Antibody

Boster Bio Anti-EVER1 TMC6 Antibody (Catalog # A07322) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance.

Synonyms

EV1, EVER1, EVIN1, LAK-4P, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1

Gene Name

TMC6

UniProt

Q7Z403

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.

Immunogen

EVER1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human EVER1. The immunogen is located within the first 50 amino acids of EVER1.

Clonality

Polyclonal

Tissue Specificity

Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes.

Applications

ELISA, WB, IHC-P

Field of Research

Homeostasis

Purification

EVER1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Probable ion channel. .

Molecular Weight

90045 MW

Shipping Conditions

Available

Storage Conditions

EVER1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.