Anti-Metalloreductase STEAP4 STEAP4 Antibody

The six-transmembrane epithelial antigen of prostate 4 (STEAP4) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP3), STEAP4 promotes both iron and copper reduction. STEAP4 is highly expressed in placenta, lung, heart and prostate tissues, and overexpressed in prostate cancer cells compared to normal prostate cells. Overexpression of STEAP4 in prostate cells significantly increases cell growth and colony formation, suggesting STEAP4 may have a role in cell proliferation and prostate cancer progression.

STEAP4 antibody was raised against a 14 amino acid synthetic peptide from near the center of human STEAP4. The immunogen is located within amino acids 210 - 260 of STEAP4.

Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.

Metalloreductase that has the ability to reduce both Fe (3+) to Fe (2+) and Cu (2+) to Cu (1+) (By similarity) . Uses NADP (+) as acceptor (By similarity) . Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity) . Associated with obesity and insulin- resistance (PubMed:18430367, PubMed:18381574) . Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107) . Inhibits anchorage-independent cell proliferation (PubMed:19787193) .

STEAP4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.