Anti-Metalloreductase STEAP1 STEAP1 Antibody

Boster Bio Anti-Metalloreductase STEAP1 STEAP1 Antibody (Catalog # A07506) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. The normal function of STEAP is still uncertain; unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity. However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers. Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy. At least three isoforms of STEAP1 are known to exist.

Synonyms

STEAP, PRSS24, STEAP, Metalloreductase STEAP1, Six-transmembrane epithelial antigen of prostate 1

Gene Name

STEAP1

UniProt

Q9UHE8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

This STEAP1 antibody does not cross-react with other STEAP proteins.

Immunogen

STEAP1 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human STEAP1. The immunogen is located within the last 50 amino acids of STEAP1.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. Highly expressed in prostate tumors.

Applications

ELISA, WB, IHC-P

Field of Research

Homeostasis, Cancer

Purification

STEAP1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Metalloreductase that has the ability to reduce both Fe (3+) to Fe (2+) and Cu (2+) to Cu (1+) . Uses NAD (+) as acceptor (By similarity) . .

Molecular Weight

39851 MW

Shipping Conditions

Available

Storage Conditions

STEAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.