Anti-NK3R TACR3 Antibody

The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.

NK3R antibody was raised against a 18 amino acid synthetic peptide from near the center of human NK3R. The immunogen is located within amino acids 370 - 420 of NK3R.

Detected in blood plasma (PubMed:24352879) . Detected in bone marrow myeloid cells (PubMed:24352879) . Detected in airway sputum (PubMed:2039600) . Detected in parotid gland secretions (PubMed:3462719) . Detected in seminal plasma (at protein level) (PubMed:3485543) . Detected in uterus cervix (PubMed:3533531) .

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B) . It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.