Anti-TIM-4 TIMD4 Antibody

Boster Bio Anti-TIM-4 TIMD4 Antibody (Catalog # A06637-1) . Tested in ELISA, WB, ICC, IF, IHC-P applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.

Synonyms

TIM4, SMUCKLER, TIM4, T-cell immunoglobulin and mucin domain-containing protein 4, T-cell immunoglobulin mucin receptor 4, TIMD-4

Gene Name

TIMD4

UniProt

Q96H15

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

At least four isoforms of TIM-4 are known to exist; this antibody will detect all four isoforms.

Immunogen

TIM-4 antibody was raised against a 16 amino acid synthetic peptide from near the center of human TIM-4. The immunogen is located within amino acids 60 - 110 of TIM-4.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.

Applications

ELISA, WB, ICC, IF, IHC-P

Field of Research

Immunology, Growth Factors, Signal Transduction

Purification

TIM-4 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity) . .

Molecular Weight

41578 MW

Shipping Conditions

Available

Storage Conditions

TIM-4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.