Anti-TIM-1 HAVCR1 Antibody

Boster Bio Anti-TIM-1 HAVCR1 Antibody (Catalog # A01306-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.

Synonyms

TIM, KIM1, TIM1, HAVCR, KIM-1, TIM-1, TIMD1, TIMD-1, HAVCR-1, Hepatitis A virus cellular receptor 1, Kidney injury molecule 1, HAVcr-1

Gene Name

HAVCR1

UniProt

Q96D42

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Anti-TIM-1 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human TIM-1. The immunogen is located within amino acids 50 - 100 of TIM-1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Immunology, Neuroscience, Signal Transduction, Growth Factors

Purification

TIM-1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity) . May play a role in kidney injury and repair.

Molecular Weight

38720 MW

Shipping Conditions

Available

Storage Conditions

TIM-1 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Other Gene Names

Hepatitis A virus cellular receptor 1

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Prediction Reactivity

Rat

Protein Name

Hepatitis A virus cellular receptor 1

Curated Selection

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