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Anti-GFR alpha 1 GFRA1 Antibody

Boster Bio Anti-GFR alpha 1 GFRA1 Antibody (Catalog # A02897) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα -1 recently. GFRα -1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK) . Thus, GDNF, GFRα and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

Synonyms

GDNFR, RET1L, RETL1, TRNR1, GDNFRA, GFR-ALPHA-1, GDNF family receptor alpha-1, RET ligand 1, GDNF receptor alpha-1

Gene Name

GFRA1

UniProt

P56159

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

GFR alpha 1 antibody is predicted to not cross-react with other members of the GFR alpha family of proteins.

Immunogen

GFR alpha 1 antibody was raised against a 14 amino acid peptide near the center of human GFR alpha 1. The immunogen is located within amino acids 360 - 410 of GFR alpha 1.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Growth Factors, Neuroscience

Purification

GFR alpha 1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) . .

Molecular Weight

51456 MW

Shipping Conditions

Available

Storage Conditions

GFR alpha 1 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A02897

Product MSDS

https://www.bosterbio.com/msds?sku=A02897

Fragment

IgG

Other Gene Names

GDNF family receptor alpha 1

Subcellular Location

Cell membrane ; Lipid-anchor, GPI-anchor .

Protein Name

GDNF family receptor alpha 1

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