KRAS G12D inhibitor 25
KRAS G12D inhibitor 25 (Compound 148) is an inhibitor for KRAS G12C and HSP90α with IC50 of EC50 of ERBB2 with a DC50 of 0.1-1 μM[1].
Product Specifications
CAS Number
[2768099-61-0]
UNSPSC
12352101
Target
EGFR; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12d-inhibitor-25.html
Smiles
C=CC(N1CCN(C[C@@H]1CC#N)C2=NC(OC[C@@H]3CCCN(C3)C(C4CCN(CC4)CC5=CC=C(C=C5)N6C(O)=NN=C6C7=C(C=C(C(C(C)C)=C7)O)O)=O)=NC8=C2CCN(C8)C9=C%10C(Cl)=CC=CC%10=CC=C9)=O
Molecular Formula
C56H62ClN11O6
Molecular Weight
1020.61
References & Citations
[1]Ying W, et al., Methods and compositions for targeting protein degradation. CN116615422A.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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