KRAS G12D inhibitor 25

KRAS G12D inhibitor 25 (Compound 148) is an inhibitor for KRAS G12C and HSP90α with IC50 of EC50 of ERBB2 with a DC50 of 0.1-1 μM[1].

Product Specifications

CAS Number

[2768099-61-0]

UNSPSC

12352101

Target

EGFR; Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kras-g12d-inhibitor-25.html

Smiles

C=CC(N1CCN(C[C@@H]1CC#N)C2=NC(OC[C@@H]3CCCN(C3)C(C4CCN(CC4)CC5=CC=C(C=C5)N6C(O)=NN=C6C7=C(C=C(C(C(C)C)=C7)O)O)=O)=NC8=C2CCN(C8)C9=C%10C(Cl)=CC=CC%10=CC=C9)=O

Molecular Formula

C56H62ClN11O6

Molecular Weight

1020.61

References & Citations

[1]Ying W, et al., Methods and compositions for targeting protein degradation. CN116615422A.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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