Ouabagenin
Ouabagenin is a naturally occurring LXR ligand with LXR selective agonist activity. Ouabagenin acts as an EC 3.6.3.9 (Na (+) /K (+) - transport ATPase) inhibitor[1][2].
Product Specifications
CAS Number
508-52-1
UNSPSC
12352005
Hazard Statement
H300-H331-H373
Target
LXR; Na+/K+ ATPase
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ouabagenin.html
Solubility
10 mM in DMSO
Smiles
OC[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@H](C[C@H]2O)O)O)([H])[C@@]4([C@](C[C@H]3O)([C@@H](C5=CC(OC5)=O)CC4)C)O
Molecular Formula
C23H34O8
Molecular Weight
438.51
Precautions
P260-P261-P264-P270-P271-P304+P340-P330-P403+P233-P405-P501
References & Citations
[1]Tamura S, et al. Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect. Sci Rep. 2018 Feb 2;8 (1) :2305.|[2]Cornelius F, et al. Interaction between cardiotonic steroids and Na, K-ATPase. Effects of pH and ouabain-induced changes in enzyme conformation. Biochemistry. 2009 Oct 27;48 (42) :10056-65.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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