Ouabagenin

Ouabagenin is a naturally occurring LXR ligand with LXR selective agonist activity. Ouabagenin acts as an EC 3.6.3.9 (Na (+) /K (+) - transport ATPase) inhibitor[1][2].

Product Specifications

CAS Number

[508-52-1]

UNSPSC

12352005

Hazard Statement

H300-H331-H373

Target

LXR; Na+/K+ ATPase

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ouabagenin.html

Solubility

10 mM in DMSO

Smiles

OC[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@H](C[C@H]2O)O)O)([H])[C@@]4([C@](C[C@H]3O)([C@@H](C5=CC(OC5)=O)CC4)C)O

Molecular Formula

C23H34O8

Molecular Weight

438.51

Precautions

P260-P261-P264-P270-P271-P304+P340-P330-P403+P233-P405-P501

References & Citations

[1]Tamura S, et al. Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect. Sci Rep. 2018 Feb 2;8 (1) :2305.|[2]Cornelius F, et al. Interaction between cardiotonic steroids and Na, K-ATPase. Effects of pH and ouabain-induced changes in enzyme conformation. Biochemistry. 2009 Oct 27;48 (42) :10056-65.