7,4'-Dihydroxyflavone

7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM) . 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex) ‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].

Product Specifications

CAS Number

[2196-14-7]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

CCR; COX; NF-κB

Type

Natural Products

Related Pathways

GPCR/G Protein; Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/7-4-dihydroxyflavone.html

Purity

99.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC=C13

Molecular Formula

C15H10O4

Molecular Weight

254.24

Precautions

H315, H319

References & Citations

[1]Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts. Phytother Res. 2017 Mar;31 (3) :449-458.|[2]Arai Y, et al. Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1) . Fitoterapia. 2015 Mar;101:51-6.