6-Thioguanine (Standard)

6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

Product Specifications

CAS Number

[154-42-7]

Product Name Alternative

Thioguanine (Standard) ; 2-Amino-6-purinethiol (Standard)

UNSPSC

12352005

Hazard Statement

H301, H351, H360

Target

Apoptosis; Autophagy; Deubiquitinase; DNA Methyltransferase; Endogenous Metabolite; Reference Standards; SARS-CoV

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/6-thioguanine-standard.html

Purity

98.41

Smiles

SC1=NC(N)=NC2=C1N=CN2

Molecular Formula

C5H5N5S

Molecular Weight

167.19

Precautions

H301, H351, H360

References & Citations

[1]Chuang SJ, et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8 (1) :3102.|[2]Wang H, et al. 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry. 2009 Mar 17;48 (10) :2290-9.|[3]LaDuke KE, et al. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am J Vet Res. 2015 Jul;76 (7) :649-55.