Sulfadoxine D3

Sulfadoxine-d3 is a deuterium labeled Sulfadoxine (HY-B0439) . Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].

Product Specifications

CAS Number

[1262770-70-6]

Product Name Alternative

Sulphadoxine D3

UNSPSC

12352005

Hazard Statement

H317-H411

Target

Antibiotic; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Purity

98.0

Solubility

10 mM in DMSO|DMSO : ≥ 100mg/mL|H2O : 0.1mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(N)C=C1)(NC2=NC=NC(OC([2H])([2H])[2H])=C2OC)=O

Molecular Formula

C12H11D3N4O4S

Molecular Weight

313.35

Precautions

P261-P272-P273-P280-P302+P352-P362+P364-P391-P501

References & Citations

[1]Ratcliff A, et al. Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia. Trans R Soc Trop Med Hyg. 2007 Apr;101 (4) :351-9. |[2]Fey K, et al. Empfindlichkeit bakterieller Krankheitserreger aus dem Respirationstrakt von Pferden gegenüber Trimethoprim, Sulfadoxin, Sulfadimethoxin und Kombinationen dieser Wirkstoffe [Susceptibility of bacterial isolates from the equine respiratory tract to trimethoprim, sulfadoxine, sulfadimethoxine and combinations of these compounds]. Tierarztl Prax. 1995 Apr;23 (2) :148-54. German. |[3]Baraff LJ. Emergency medicine-important advances in clinical medicine: single-dose treatment of urinary tract infections. West J Med. 1983 Jan;138 (1) :89-90. |[4]Oguariri RM, et al. Evaluation of the effect of pyrimethamine, an anti-malarial drug, on HIV-1 replication. Virus Res. 2010 Nov;153 (2) :269-76. |[5]Neerja J, et al. Plasmodium yoelii: activity of azithromycin in combination with pyrimethamine or sulfadoxine against blood and sporozoite induced infections in Swiss mice. Exp Parasitol. 2004 Jul-Aug;107 (3-4) :120-4.