Human AREG Protein

AREG is a one-way membrane protein consisting of 252 amino acids. AREG belongs to AREG family and contains an EGF-like domain. AREG is expressed in many tissues, including ovary, placenta, lung, kidney, stomach, colon and breast. It is related to epidermal growth factor (EGF) and transforming growth factor α (TGF-α). As an EGF-related growth factor, AREG interacts with EGF/TGF-α receptor to promote the growth of normal epithelial cells and inhibit the growth of some invasive cancer cell lines.