Human GDF 5 Protein

Human GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the Human GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of Human GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Recombinant Human GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.

Product Specifications

Background

Product Name Alternative

Growth differentiation factor 5; Growth/differentiation factor 5; H-GDF-5

Gene ID

8200

Accession Number

P43026

Tag

GDF5

Type

Cytokines and proteins

Applications

No tag

Purity

> 98 % as determined by SDS-PAGE

Activity

Testing in progress

Molecular Weight

13.5 kDa

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Features & Benefits

Endotoxin: < 1 EU per μg of the protein as determined by the LAL method.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Lyophilized recombinant Human GDF5 protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.

Protein Length

The recombinant Human GDF5 consists of 120 amino acids and predicts a molecular mass of 13.5 kDa.

Formulation

Lyophilized from 40 mM Tris-HCl pH 8.0, 50 mM NaCl.

Applications Notes

Human

Other Product Names

Growth differentiation factor 5; Growth/differentiation factor 5; H-GDF-5

Recommended Usage

Centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant Human GDF5 protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.