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Human β-NGF protein, His tag (Animal-Free)

Nerve Growth Factors (NGF) is critical for the development and maintenance of the sympathetic and sensory neuron systems. NGF has been demonstrated as a complex that consists of three polypeptides named α, β and γ subunits. Among then, β subunit, which known as beta-NGF is a 26.9 kDa protein containing 241 residues that involve in neuronal survival and differentiation. Besides, beta-NGF also acts as a ligand to TRKA receptor, which indispensable for the differentiation and development of pain and temperature sensing neurons.

Product Specifications

Background

Beta-Nerve Growth Factor (β-NGF), also known as Beta-NGF, NGF, NGFB, is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. β-NGF can also downregulate the production of IFN-γ by T cells. Recombinant β-NGF has been used in many clinical trials to treat different disease including Alzheimer's disease, diabetic polyneuropathy, and HIV-associated peripheral neuropathy

Product Name Alternative

β-Nerve Growth Factor, NGF-β

Accession Number

P01138

Tag

β-NGF

Type

Cytokines and proteins

Applications

His tag

Purity

>98% as determined by SDS-PAGE.

Activity

Measure by its ability to induce TF-1 cells proliferation.The ED₅₀ for this effect is <0.7 ng/mL.The specific activity of recombinant human beta-NGF is > 1 x 10⁶ IU/mg.

Molecular Weight

The protein has a calculated MW of 14.43 kDa. The protein migrates as 11 kDa under reducing condition (SDS-PAGE analysis) .

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Features & Benefits

Endotoxin:<0.1 EU per 1 μg of the protein by the LAL method.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Lyophilized protein product should be stored desiccated below -18°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (5% HSA , 10%FBS or 0.1%BSA) . Please prevent freeze-thaw cycles

Protein Length

The secreted Human β-NGFconsists of 120 amino acids and has a predicted molecular mass of 13.5 kDa

Formulation

The secreted Human β-NGFconsists of 120 amino acids and has a predicted molecular mass of 13.5 kDa

Applications Notes

Human

Other Product Names

β-Nerve Growth Factor, NGF-β

Recommended Usage

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant Human β-NGF protein to a concentration of 0.1-1 mg/mL in sterile ddH2O, and keep at room temperature for at least 20 min to fully dissolve. Please avoid vortex vigorously

Preparation

E. coli

AA Sequence

Amino acid sequence derived from Human β-NGF (Ser122-Ala241) (P01138) was expressed with 6xHis tag at the C-terminus

Available Sizes

Frequently Asked Questions

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