Human Noggin protein, His tag (Animal-Free)
Noggin is a 46.2 kDa bioactive protein, which exists as a disulfide-linked homodimer (each chain 23.1 kDa) . Noggin binds members of the transforming Growth Factors-beta (TGF beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP-4), which inactivates their activities. As a extracellular antagonist of BMP proteins, Noggin involves in the development of many body tissues, including nerve tissue, muscles, and bones. In addition, Noggin is able to inhibit chondrocyte differentiation through its interaction with GDF5.
Product Specifications
Background
Product Name Alternative
NOG, Noggin, SYM1, symphalangism 1 (proximal), synostoses (multiple) syndrome 1, SYNS1, SYNS1A
Accession Number
Q13253
Tag
Noggin
Type
Cytokines and proteins
Applications
His tag
Purity
>98% as determined by SDS-PAGE.
Activity
Molecular Weight
The protein has a calculated MW of 49.11 kDa. The protein migrates as 27 kDa under reducing condition (SDS-PAGE analysis) .
Precautions
Features & Benefits
Endotoxin:<0.1 EU per 1 μg of the protein by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Protein Length
The secreted Human Noggin consists of 205 amino acids and has a predicted molecular mass of 27 kDa
Formulation
Applications Notes
Human
Other Product Names
NOG, Noggin, SYM1, symphalangism 1 (proximal), synostoses (multiple) syndrome 1, SYNS1, SYNS1A
Recommended Usage
Preparation
E. coli
AA Sequence
Amino acid sequence derived from Human Noggin (Gln28-Cys232) (NP_005441.1) was expressed with 6xHis tag at the C-terminus
Available Sizes
Explore Other Products
Browse additional items from our catalog
