Malonyl-NAC
Malonyl-NAC increases cellular propylation, resulting in reduced endogenous GAPDH activity. malonyl-NAC increases GAPDH malonylation in cells and inhibits pyruvate kinase activity. In addition, malonyl-NAC limits the metabolism and proliferation of a highly glycolytic kidney cancer cell line harboring a tricarboxylic acid cycle mutation[1].
Product Specifications
CAS Number
[2361327-06-0]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Pyruvate Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/malonyl-nac.html
Concentration
10mM
Purity
98.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC(SCCNC(C)=O)=O)OCC
Molecular Formula
C9H15NO4S
Molecular Weight
233.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Kulkarni RA, et al. Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling. Cell Chem Biol. 2017 Feb 16;24 (2) :231-242.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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