Solasodine

Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities[1][2].

Product Specifications

CAS Number

[126-17-0]

Product Name Alternative

Purapuridine; Solancarpidine; Solasodin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; E1/E2/E3 Enzyme; Fungal; MDM-2/p53

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Solasodine.html

Purity

99.81

Solubility

DMSO : 1.96 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C) |Ethanol : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

C[C@H](CC1)CN[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C

Molecular Formula

C27H43NO2

Molecular Weight

413.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Lecanu L, et al. The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo. Neuroscience. 2011 Jun 2;183:251-64.|[2]Chauhan K, et al. Anticonvulsant activity of solasodine isolated from Solanum sisymbriifolium fruits in rodents. Pharm Biol. 2011 Feb;49 (2) :194-9.|[3]Akhtar S, et al. Evaluation and Elucidation Studies of Natural Aglycones for Anticancer Potential using Apoptosis-Related Markers: An In silico Study. Interdiscip Sci. 2018 Jun;10 (2) :297-310.