Alantolactone
Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer[1][2][3].
Product Specifications
CAS Number
546-43-0
Product Name Alternative
(+) -Alantolactone; Alant camphor; Inula camphor
UNSPSC
12352005
Hazard Statement
H317
Target
Apoptosis; STAT; TGF-beta/Smad
Type
Natural Products
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Alantolactone.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O[C@@]1([H])[C@]2([H])C=C3[C@@H](C)CCC[C@]3(C)C1)C2=C
Molecular Formula
C15H20O2
Molecular Weight
232.32
Precautions
H317
References & Citations
[1]Khan M, et al. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. Biomed Res Int. 2013;2013:719858.|[2]Chun J, et al. Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Cancer Lett. 2015 Feb 1;357 (1) :393-403.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
STAT3
Available Sizes
Frequently Asked Questions
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