Alantolactone

Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer[1][2][3].

Product Specifications

CAS Number

[546-43-0]

Product Name Alternative

(+) -Alantolactone; Alant camphor; Inula camphor

UNSPSC

12352005

Hazard Statement

H317

Target

Apoptosis; STAT; TGF-beta/Smad

Type

Natural Products

Related Pathways

Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Alantolactone.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O[C@@]1([H])[C@]2([H])C=C3[C@@H](C)CCC[C@]3(C)C1)C2=C

Molecular Formula

C15H20O2

Molecular Weight

232.32

Precautions

H317

References & Citations

[1]Khan M, et al. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. Biomed Res Int. 2013;2013:719858.|[2]Chun J, et al. Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Cancer Lett. 2015 Feb 1;357 (1) :393-403.