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SLF80821178

SLF80821178 is a potent and orally active inhibitor of Sphingosine-1-Phosphate Transporter (Spns2) . SLF80821178 inhibits S1P release with an IC50 of 51 nM in HeLa cells and a T1/2 of 2.4 h in mouse[1].

Product Specifications

CAS Number

2764877-61-2

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/slf80821178.html

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCNCC1)NC2=CC=C(CCCCCCCCCC)C=C2

Molecular Formula

C21H35N3O

Molecular Weight

345.52

References & Citations

[1]Foster DJ, et al. Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. J Med Chem. 2024 Jul 11;67 (13) :11273-11295.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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