SC428

SC428 is an androgen receptor (AR) inhibitor that targets the N-terminal domain. SC428 potently decrease the transactivation of (AR) -V7, (AR) v567es, as well as full-length (AR) (AR-FL) and its LBD mutants, substantially. SC428 inhibits androgen-stimulated (AR) -FL nuclear translocation, chromatin binding, and (AR) -regulated gene transcription. SC428 inhibits the proliferation of tumor cells in vitro. SC428 inhibits tumor cell growth by inducing apoptosis in mice transplanted with 22RV1[1].

Product Specifications

CAS Number

[1898232-70-6]

UNSPSC

12352100

Target

Androgen Receptor; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sc428.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N#CC1=CC=C(NC(N/C=C/C2=CC=CS2)=O)C=C1C(F)(F)F

Molecular Formula

C15H10F3N3OS

Molecular Weight

337.32

References & Citations

[1]Qianhui Yi , et al. Discovery of a Small-Molecule Inhibitor Targeting the Androgen Receptor N-Terminal Domain for Castration-Resistant Prostate Cancer. 2023 May 4;22 (5) :570-582.